Does garlic oil have a role in the treatment of Helicobacter pylori infection ?
Küçük Resim Yok
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Helicobacter pylori (H. pylori), nonspesifik kronik gastrit ve peptik ülser hastalığının patogenezinde rolü olan en önemli faktörlerden biri olarak kabul edilmekte¬dir. Ancak, henüz ideal bir tedavi şekli belirlenememiş¬tir. Alliurn sativum'un (garlic) hemen hemen tüm bakte¬rilere karşı etkili olduğu gösterilmiştir. Garlic oil'in tek başına ya da proton pompası inhibitörü omeprazol ile kombine olarak H. pylori infeksiyonunun tedavisinde et¬kili olup olmadığının belirlenmesi amacıyla, dispeptik yakınmaları olan 20 H. pylori(+) hasta çalışmaya alın¬dı. Garlic oil 3X275mg dozda tek başına (n=10) ya- da omeprazol 2X20mg ile kombine olarak (n=10) iki hafta süreyle verildi. Tedavinin tamamlanmasından bir ay sonra hastalar tekrar değerlendirildi ve tümünde H. pylori infeksiyonunun halen devam ettiği saptandı. His¬tolojik olarak, kronik aktif gastrit bulgularında ve H. pylori yoğunluğunda da değişiklik görülmedi. Sonuç olarak, garlic oil kapsüllerinin H. pylori infeksiyonu¬nun tedavisinde herhangi bir etkisinin olmadığı sap¬tandı. Bu konunun kesin olarak belirlenebilmesi için, taze sarmısak ekstreleri gibi, esas antibakteriyel kom-ponent olan allicin'i daha fazla içeren ürünlerle yapılacak ileri çalışmalara gerek vardır..
Helicobacter pylori (H. pylori) is generally accepted as one of the most important factors in the pat¬hogenesis of nonspecific chronic gastritis and peptic ul¬cer disease. However, an ideal treatment schedule is not yet available. It has been shown that allium sativum (garlic) has a wide effect against almost all kinds of bac¬teria. In order to investigate whether garlic oil has a ro¬le in the treatment ofH. pylori infection, alone or combi¬ned with proton pump inhibitor omeprazole, 20 H. pylori (+) patients with dyspeptic complaints were studi¬ed. Patients were assigned to receive either garlic oil 275 mg caps t.i.d (n=10) or garlic oil 275 mg caps t.i.d. plus omeprazole 20 mg caps b.i.d. (n=10) for two weeks. One month after discontinuation of treatment, the patients were re-assessed and all of them were still found as H. pylori (+). H. pylori density and histological findings of active chronic gastritis were unchanged. In conclusion, this study showed no effect of garlic oil capsules on H. pylori infection. It needs further studies with other pro¬ducts such as fresh garlic extracts which contain much more allicin, the main antibacterial component.
Helicobacter pylori (H. pylori) is generally accepted as one of the most important factors in the pat¬hogenesis of nonspecific chronic gastritis and peptic ul¬cer disease. However, an ideal treatment schedule is not yet available. It has been shown that allium sativum (garlic) has a wide effect against almost all kinds of bac¬teria. In order to investigate whether garlic oil has a ro¬le in the treatment ofH. pylori infection, alone or combi¬ned with proton pump inhibitor omeprazole, 20 H. pylori (+) patients with dyspeptic complaints were studi¬ed. Patients were assigned to receive either garlic oil 275 mg caps t.i.d (n=10) or garlic oil 275 mg caps t.i.d. plus omeprazole 20 mg caps b.i.d. (n=10) for two weeks. One month after discontinuation of treatment, the patients were re-assessed and all of them were still found as H. pylori (+). H. pylori density and histological findings of active chronic gastritis were unchanged. In conclusion, this study showed no effect of garlic oil capsules on H. pylori infection. It needs further studies with other pro¬ducts such as fresh garlic extracts which contain much more allicin, the main antibacterial component.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
2
