Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Soc Stem Cell Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the potential to modulate the tumor cells. MSCs have been established with double functions, whereby contribute to a tumorigenic or anti-tumor setting. Clinical studies have indicated the potential of MSCs to be used as tool in treating the human cancer cells. One of the advantageous features of MSCs that make them as a well-suited tool for cancer therapy is the natural tumor-trophic migration potential. A key specification of the tumor development has been stablished to be angiogenesis. As a result, manipulation of angiogenesis has become an attractive approach for cancer therapy. This review article will seek to clarify the anti-angiogenesis strategy in modulating the MSCs to treat the tumor cells.
Açıklama
Anahtar Kelimeler
Mesenchymal stem cells, Angiogenesis, Cancer therapy, Tumor microenvironment, Endothelial Growth-Factor, Umbilical-Cord Blood, Human Bone-Marrow, Tyrosine Kinase Inhibitor, Double-Edged-Sword, Stromal Cells, In-Vitro, Lung-Cancer, Progesterone-Receptors, Tissue Distribution
Kaynak
International Journal of Stem Cells
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
14
Sayı
4
