Synthesis, characterization and biodistribution of Tc-99m-Bioquin-HMPAO (Tc-99m-BH) as a novel brain imaging agent

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dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorMuftuler, Fazilet Zumrut Biber
dc.contributor.authorEnginar, Huseyin
dc.contributor.authorTekin, Volkan
dc.contributor.authorMedine, Emin Ilker
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T22:13:02Z
dc.date.available2019-10-27T22:13:02Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractRecently, the development of novel brain imaging agents has aroused much interest thanks to limited number of brain cancer or diseases diagnosis agents. It is aimed to synthesize a novel brain imaging agent including a promise for further studies on AD diagnosis potential and investigate its bioaffinity with biodistribution studies on healthy Balb/c mice. A novel radiolabeled agent was synthesized and characterized. Quality control of Tc-99m-BH was performed utilizing solvent extraction and chromatographic (Radio TLC and Radio HPLC) methods. Bioaffinity of the Tc-99m-BH was investigated on male Balb/c mice at various time points (5, 30, 60, 120 min post-injection). Paper electrophoresis showed that Tc-99m-BH has a neutral structure. Radiochemical purity of Tc-99m-BH was over 95 % with appropriate stability for imaging period. Selected brain regions have uptakes over 4 % ID/g following intravenous injection. Hippocampus has uptake approximately 10 % ID/g. Tc-99m-BH has shown brain uptake, so it may prove to be valuable for brain imaging as a novel technetium-labeled agent. Further investigations with AD animal model are our on going effort to show that this agent has AD diagnosis potential.en_US
dc.description.sponsorshipEge University Research FundEge University [2011 NBE 003]en_US
dc.description.sponsorshipThis work is supported by Ege University Research Fund (contract no 2011 NBE 003). The authors thank to Eser Ucar, Cansu Uzaras, Kadir Ari and Baris, Yilmaz for the technical assistance during the animal experiments.en_US
dc.identifier.doi10.1007/s10967-014-3175-1
dc.identifier.endpage573en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue1en_US
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3175-1
dc.identifier.urihttps://hdl.handle.net/11454/49676
dc.identifier.volume302en_US
dc.identifier.wosWOS:000342134800066en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain imagingen_US
dc.subjectHMPAOen_US
dc.subjectBioquinen_US
dc.subjectTc-99men_US
dc.titleSynthesis, characterization and biodistribution of Tc-99m-Bioquin-HMPAO (Tc-99m-BH) as a novel brain imaging agenten_US
dc.typeArticleen_US

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