The role of Tc-99(m)-tetrofosmin myocardial perfusion scintigraphy in the assessment of patients with previous myocardial infarction: A comparative study with Tl-201
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to determine the utility of Tc-99(m)-tetrofosmin cardiac imaging in patients with previous myocardial infarction and with significant coronary artery disease (CAD) compared with that of Tl-201 cardiac imaging. Sixteen patients (14 males, 2 females) were studied by same-day exercise-rest Tc-99(m)-tetrofosmin imaging and exercise, rest and reinjection Tl-201 cardiac imaging. For each study, semiquantitative visual analysis was performed in 20 segments using a 4-point scale. The regional distribution and defect reversibility with the two tracers were compared with the results of coronary angiography. A total of 320 segments were analysed. There was a statistically significant concordance between the numbers of fixed and reversible segments in both studies in myocardial segments supplied by totally occluded coronary arteries (Group 1), as well as in segments supplied by significantly stenosed coronary vessels (Group 2). The exercise and rest uptake of both Tc-99(m)-tetrofosmin and Tl-201 in myocardial segments supplied by totally occluded coronary arteries with poor collateral flow was significantly lower compared with segments supplied by totally occluded coronary arteries with efficient collateral flow (P less than or equal to 0.05). When the uptake of both tracers was analysed according to each major vascular territory, the mean exercise and rest uptake grades of Tc-99(m)-tetrofosmin and Tl-201 were similar. There was also no significant difference in defect reversibility between the two tracers. Discordant results were observed in the territory of the right coronary artery in Group 1 (mean exercise grade of Tc-99(m)-tetrofosmin=2.26+/-0.7 and of Tl-201=1.92+/-0.8; P less than or equal to 0.001) and in Group 2 (mean grade of Tc-99(m)-tetrofosmin=0.79+/-0.65 and of Tl-201=0.95+/-0.65; P less than or equal to 0.05). The results of the present study indicate that the overall diagnostic utility of Tc-99(m)-tetrofosmin in the identification of individual stenosed vessels is comparable with Tl-201 in both patients with totally occluded coronary arteries and those with significantly stenosed vessels. The regional distribution of both tracers was lower in myocardial segments supplied by totally occluded coronary arteries with poor collateral flow.
Açıklama
Anahtar Kelimeler
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
19
Sayı
2
