Levels of interleukin-6 (IL-6) and its soluble receptor (sIL-6R) in familial Mediterranean fever (FMF) patients and their first degree relatives
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective. Familial Mediterranean Fever (FMF) is a hereditary disease characterized by recurrent inflammatory attacks. A subclinical inflammation may persist in periods between the attacks and heterozygotes may have higher than normal levels of acute phase proteins. We investigated the levels of interleukin-6 (IL-6) and its soluble receptor (sIL-6R) in FMF patients and their obligatory carrier relatives. Methods. Serum levels of IL-6 and sIL-6R were measured during acute attacks (n = 18) and in attack-free FMF patients (n = 26), obligatory carriers of FMF (n = 17) and normal controls (n = 11). Results. The median levels of IL-6 were significantly higher (45.71 pg/mL, p = 0. 001) during acute attacks of FMF only, and were normal (0.01 pg/mL) in the other groups studied. There was no statistically significant difference in the median sIL-6R values between any of the groups (p = 0.22). Conclusion. IL-6 was extremely elevated during FMF attacks but could not detect hypothetical "subclinical" inflammation during attack-free intervals or in the heterozygote relatives of patients. Serum levels of sIL-6R were comparable in all four groups. © Copyright Clinical and Experimental Rheumatology 2004.
Açıklama
Anahtar Kelimeler
Familial Mediterranean fever (FMF), FMF carriers, IL-6, sIL-6R
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
22
Sayı
4 SUPPL. 24
