MicroRNA-Based Biomarkers in Lung Cancer: Recent Advances and Potential Applications
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that post-transcriptionally control the expression of genes by binding and degrading their target mRNAs. miRNAs can function as possible tumor suppressors or oncogenes in various cancers. Lately, miRNAs application as a biomarker (prognosis and diagnosis) for different diseases has gained much attention. miRNAs exist in a stable form in several biological materials, including tissue, plasma, and serum. The noninvasive and easy screening of miRNAs in serum, blood, tissue, and other body fluids and acceptable stability make microRNA a noticeable factor as biomarkers in human malignancies. Materials and Methods: In this review, we searched some online databases like Web of Science, Embase, and PubMed to find eligible manuscripts up to the end of 2021. Results: Abnormal expressions of these molecules are associated with the incidence of many illnesses like cancer. Therefore, they are candidates as a molecular tool for noninvasive tumor prognosis and diagnosis. In the current study, we introduce important miRNAs that may be used as prognostic and diagnostic markers in lung cancer patients. Conclusion: We summarized the latest reports about critical miRNAs related to the diagnosis and prognosis in lung patients. © 2023 Bentham Science Publishers.
Açıklama
Anahtar Kelimeler
biomarker, diagnosis, Lung cancer, miRNA, NSCLC, prognosis, biological marker, microRNA, microRNA 1, microRNA 126, microRNA 1290, microRNA 154, microRNA 15a, microRNA 205, microRNA 21, microRNA 30a, microRNA 411, microRNA 486, microRNA 520f, microRNA 638, microRNA 9, microRNA 98, unclassified drug, messenger RNA, microRNA, tumor marker, blood, body fluid, cancer screening, human, incidence, lung cancer, mRNA expression level, non invasive procedure, Review, sensitivity and specificity, serum, systematic review, tumor suppressor gene, gene expression regulation, genetics, lung tumor, metabolism, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, MicroRNAs, RNA, Messenger
Kaynak
Current Molecular Medicine
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
23
Sayı
7
