Development and Optimization of Self-emulsifying Drug Delivery Systems (SEDDS) for Enhanced Dissolution and Permeability of Rosuvastatin
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science Publ Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Rosuvastatin calcium is commonly used statin for treatment of dyslipidemia. It has low bioavailability. The aim of this study was to develop new rosuvastatin calcium self-emulsifying drug delivery systems (SEDDS) as an alternative formulation and to evaluate the permeability of rosuvastatin calcium SEDDS by using Caco-2 cells. Rosuvastatin calcium SEDDSs were developed by using pseudo ternary phase diagram and characterized by using heating cooling cycle, robustness to dilution, stability and in vitro drug release and permeability. The permeability studies of rosuvastatin calcium SEDDS (P-app (A -> B) for F1-RS = 1.492x10(-5)+/- 0.413x10(-5) and Papp (A. B) for F2-RS= 1.254x10(-5)+/- 0.19x10(-5)) across Caco-2 cells showed that permeability value from apical to basolateral was higher than permeability value of commercial formulation (Papp (A -> B) = 7.13x10(-5)+/- 0.668x10(-5)). In conclusion, SEDDS as a drug carrier may be used as an effective and alternative hyperlipidemia therapy for oral delivery of rosuvastatin calcium.
Açıklama
11th International Symposium on Pharmaceutical Sciences (ISOPS) -- JUN 09-12, 2015 -- Ankara Univ, Fac Pharm, Ankara, TURKEY
Anahtar Kelimeler
Drug delivery system, Rosuvastatin, self-emulsifiying
Kaynak
Current Drug Delivery
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
13
Sayı
3
