New therapeutic system based on hydrogels for vaginal candidiasis management: formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent gynecological disorders. Various antifungal drugs are used for its treatment, with Terbinafine being one of them. in this study, new gel formulations were prepared for Terbinafine vaginal delivery. Natural polymers such as chitosan, sodium carboxymethylcellulose, and Carbopol were used for the development of Terbinafine vaginal gels. the developed gels were examined for their viscosity and spreadability, pH and mechanical properties. the most optimal formulations were further evaluated for theirin vitrorelease behavior and antifungal activities. in further, the cytotoxicity and irritation inducing capacity of optimum gel formulations were evaluated.In vitrodrug release studies demonstrated that terbinafine release was prolonged whereas anti-candida activity in several species showed the superiority of the gels compared to the marketed product. G-5 and G-8 gels did not cause lysis, hemorrhage and coagulation, therefore, classified as non-irritant. the optimal formulations were also studied for their stability, demonstrating that they were stable for 3 months.
Açıklama
Anahtar Kelimeler
Vaginal delivery, terbinafine, hydrogels, HET-CAM, chitosan, Carbopol, sodium carboxymethylcellulose
Kaynak
Pharmaceutical Development and Technology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
25
Sayı
10
