Triterpene glycosides from astragalus angustifolius
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Six new cycloartane-type (1-6) and four new oleanane-type (7-10) triterpene glycosides were isolated from Astragalus angustifolius Lam., together with five known triterpene glycosides. Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analysis. Compounds 1-3 are glycosides of cycloastragenol, while compounds 4-6 show the C-24 epimer of cycloastragenol as aglycone, encountered for the first time in nature. All compounds were evaluated for their antiproliferative activity in Hela, H-446, HT-29, and U937 cell lines. Only compound 8 displayed a weak activity with IC 50 values of 36 and 50 µM against Hela and HT-29 cell lines, respectively. © Georg Thieme Verlag KG Stuttgart · New York.
Açıklama
Anahtar Kelimeler
Astragalus angustifolius, cycloartane saponins, Leguminosae, oleanane saponins
Kaynak
Planta Medica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
78
Sayı
7
