Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease's progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.
Açıklama
Anahtar Kelimeler
COVID-19, oxidative stress, antioxidant enzymes, genetics, anti-oxidative therapies, glutathione, N-acetylcysteine, N-Acetylcysteine, Promoter Polymorphisms, Glutathione-Peroxidase, Adjuvant Therapy, G6pd Deficiency, Inflammation, Cells, Association, Neutrophil, Expression
Kaynak
Antioxidants
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
11
Sayı
8
