MONOCLONAL ANTIBODIES USED IN CANCER DIAGNOSIS AND TREATMENT
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Cancer is a disease that develops with the uncontrolled proliferation of cells in the body and is characterized by abnormal and uncontrolled growth of cells. While the incidence of cancer is increasing day by day, new approaches in the diagnosis and treatment of cancer are gaining great importance. Anatomical imaging techniques and nuclear imaging systems are frequently used for cancer diagnosis. In the treatment of cancer, in addition to traditional approaches (surgery, radiotherapy, chemotherapy), targeted approaches have been used recently. Targeted approaches in cancer treatment mostly include small molecule tyrosine kinase inhibitors and monoclonal antibodies. Monoclonal antibodies were initially obtained from hybridomas formed by B cells and myeloma cancer cells of antigen-immunized mice. It is mostly used in the diagnosis, purification and analysis of biological materials, diagnosis and treatment of cancer, and prevention of tissue rejection in organ transplants. Monoclonal antibodies have great advantages because they take less time to develop and cost less. In addition to these advantages, although different side effects have been detected in the direction of research, monoclonal antibodies are in great demand today due to their target specificity and other advantages. Result and Discussion: Although research on monoclonal antibodies and cancer diagnosis and treatment continue today, this subject continues to be an important and curious subject in terms of medical science. In this review, monoclonal antibodies, which are frequently used in cancer diagnosis and treatment, and their targets, mechanisms of action and clinical uses will be discussed. © 2023 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
Cancer diagnosis, cancer treatment, Monoclonal antibody, monoclonal antibody, Article, cancer diagnosis, cancer therapy, malignant neoplasm, molecularly targeted therapy, nonhuman
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
47
Sayı
1
