Schiff Base-platinum and ruthenium complexes and anti-Alzheimer properties
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Scince Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (1H, 13C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (A beta 1-42) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of A beta 1-42 with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 1H NMR spectroscopy examined the interaction with A beta 1-16. Electrochemical analysis using square wave voltammetry monitored the interaction with A beta 1-42. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.
Açıklama
Anahtar Kelimeler
Amyloid beta (Aβ1–42), Anti-Alzheimer activity, Electrochemical analysis, Pt complexes, Ru complexes, Schiff base
Kaynak
Journal of Inorganic Biochemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
264
Sayı
Dec
Künye
Günnaz, S., Yildiz, E., Tunçel Oral, A., Yurt, F., Erdem, A., & Irişli, S. (2025). Schiff Base–platinum and ruthenium complexes and anti-alzheimer properties. Journal of Inorganic Biochemistry, 264, 112790.
