Effect of acetophenone derived Mannich bases on cellular glutathione level in jurkat cells - A possible mechanism of action
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ecv-Editio Cantor Verlag Medizin Naturwissenschaften
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effect of the acetophenone derived mono Mannich bases 1-3 and his Mannich base 7 (his derivative of compound 3) on cellular glutathione level was investigated in Jurkat cells. The cells were exposed to the compounds in phosphate buffered saline for I h in 37 degreesC with gentle shaking and then glutathione level was measured. Especially, mono Mannich base 3 and its his derivative 7 decreased total glutathione level in a dose-dependent manner. The results provide further support for the thiol alkylation mechanism explaining the cytotoxic activity of Mannich bases.
Açıklama
Anahtar Kelimeler
Acetophenone derivatives, effects on cellular glutathione levels, in vitro studies, Glutathione, Mannich bases, cytotoxic activity, mechanism of action
Kaynak
Arzneimittel-Forschung-Drug Research
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
51
Sayı
8
