Experimental olarak Toxoplasma gondii ile enfekte edilen farelerde nitrik oksit metabolitleri
Küçük Resim Yok
Tarih
2002
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Dergi Başlığı
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Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Toxoplasma gondii enfeksiyonu sırasında NO üretiminin intrasellüler parazitleri öldürebildiği fakat konak için de zararlı etkiler gösterdiği bilinmektedir. Çalışmamızda insan modeli olarak seçilen experimental şekilde T. gondii ile enfekte edilmiş olan farelerde karaciğer dokusu ve serum seviyelerinde kontrol grubu ile karşılaştırıldığında anlamlı ölçüde yüksek NO yıkım ürünleri bulunmuştur. Ayrıca toxoplasmosisli farelere NO sentez inhibitörü olarak Aminoguanidine verilmiş, bu grup T. gondii ile enfekte edilmiş grupla karşılaştırıldığında karaciğerde hepatosit morfolojisinin korunduğu ve yağ dejenerasyonunun daha az oranda görüldüğü gözlenmiş, sonuçta NO'in konak savunmasında görev yaparken aynı zamanda ona zararlı etkilerinin de olabileceği gösterilmiştir.
During Toxoplasma gondii infection, the production of NO kills the intracellular parasites, but it also damages the host. in our study, in the mice chosen as our human model and infected experimentally with T. gondii, it was found that the liver tissue and serum levels of NO destruction products were significantly higher as compared to the control group. Furthermore, aminoguanidine was given as a NO synthesis inhibitor to the mice with toxoplasmosis and this group was compared with a group infected with T, gondii but not given the drug. It was found that in the mice given aminoguanidine, the hepatocyte morphology in the liver was protected and the lipid degeneration was less. Thus, it has been shown that although NO enhances host immunity, it can also be destructive for the host.
During Toxoplasma gondii infection, the production of NO kills the intracellular parasites, but it also damages the host. in our study, in the mice chosen as our human model and infected experimentally with T. gondii, it was found that the liver tissue and serum levels of NO destruction products were significantly higher as compared to the control group. Furthermore, aminoguanidine was given as a NO synthesis inhibitor to the mice with toxoplasmosis and this group was compared with a group infected with T, gondii but not given the drug. It was found that in the mice given aminoguanidine, the hepatocyte morphology in the liver was protected and the lipid degeneration was less. Thus, it has been shown that although NO enhances host immunity, it can also be destructive for the host.
Açıklama
Anahtar Kelimeler
Parazitoloji, Genel ve Dahili Tıp
Kaynak
Türkiye Parazitoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
1
