Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients
Küçük Resim Yok
Tarih
1998
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Librapharm
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Defective endothelium-dependent vascular relaxation has been found in animal models of hypertension and in hypertensive patients. An inbalance due to reduced production of nitric oxide (NO) or increased production of free radicals, mainly the superoxide anion, may facilitate the development of an arterial functional spasm. Although it has been shown that many antihypertensive drugs can normalise both tire antioxidant activity and NO, the antioxidant effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341), an alpha-adrenoreceptor agonist, has not been investigated. In this study the investigated tire antioxidant and NO status in hypertensive patients and whether there was any effect of S-3341 or? these parameters. Eleven patients with mild hypertension (mean systolic blood pressure 159.5 +/- 2.5 mmHg) were administered S-3341 (1 mg/day) for 4 weeks. Plasma vitamin E, nitrite-nitrate and MDA levels, and catalase activity, were measured both before and after treatment with S-3341. There was significant reduction in both mean systolic and diastolic blood pressure during the treatment. We found an increase irt catalase activity (p < 0.05), a decrease in malondialdehyde (MDA) levels (p < 0.01) and an insignificant increase in vitamin E In els in hypertensive patients following tire S-3341 treatment. We propose that S-3341 may prevent oxidant stress in hypertensive patients by inhibiting free-radical formation.
Açıklama
Anahtar Kelimeler
hypertension, catalase, vitamin E, malondialdehyde, nitrites, nitrates, N-dicyclopropylmethyl-amino-2-oxazoline
Kaynak
Current Medical Research and Opinion
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
14
Sayı
2
