Agmatine produces antinociception in tonic pain in mice
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Agmatine is an endogenous polyamine metabolite formed by decarboxylation of L-arginine. In this study, the effect of agmatine on tonic pain was compared to its effect on phasic pain by using the formalin and tail-flick (TF) teats in mice. When administered intraperitoneally (ip), agmatine (37.5-300 mg/kg) exhibited a decrease in nociceptive behaviours in the first and second phase of the formalin test, which is a tonic pain model. The alpha (2) adrenoceptor antagonist yohimbine blocked the effect of agmatine in Phase 2 but did not change its effect in Phase I. In the TF test, there was no significant change in the behaviour of agmatine-administered (75-300 mg/kg) animals. As a result, agmatine appears to have an analgesic effect on tonic rather than phasic pain, and alpha (2) receptors seem partly to have a role in the antinociceptive effect of agmatine on tonic pain. (C) 2001 Elsevier Science Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
agmatine, tonic, pain, mice
Kaynak
Pharmacology Biochemistry and Behavior
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
69
Sayı
01.Feb
