Cycloartane Glycosides from Astragalus erinaceus

One new cycloartane-type saponin, 3-O-[beta-D-xylopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-6-O-beta-D-glucuronopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxyxyxloartane (1) was isolated from the MeOH extract of whole plant parts of Astragalus erinaceus along with 5 known saponins (2-6), cyclodissectoside, cycloastragenol, 6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxycycloartane, oleifolioside B and 3,6-di-O-beta-D-xylopyranosyl-3 alpha,6 beta,16 beta,24(S),25-pentahydroxycycloartane, respectively. Their structures were established by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The glucuronic acid moiety in cycloartanes is a very unusual finding.