Tumor necrosis factor-alpha gene promoter polymorphism in patients with familial Mediterranean fever
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays an important role on the course of disease in familial Mediterranean fever (FMF). TNF-alpha gene promoter polymorphism may be a marker of susceptibility and severity of FMF. The aim of this study is to evaluate both TNF-alpha/238 and TNF-alpha/308 genotypes and allelic distribution in patients with FMF. Forty-one FMF patients and 43 healthy volunteers were included in the study. Genomic DNA was extracted from EDTA-preserved whole blood of whole series of patients and controls. Polymorphism of TNF-alpha promoter at positions -238 and -308 were detected by using amplification refractory mutation system polymerase chain reaction. TNF-alpha/238 and TNF-alpha/308 genotype distributions and allele frequencies of FMF patients and healthy volunteers were found to be similar. Moreover, there was no association between TNF-alpha/238 and TNF-alpha/308 genotypes and the frequency of acute attacks in FMF. TNF-alpha/238 and TNF-alpha/308 promoter polymorphisms do not seem to be major genetic risk factors for susceptibility to FMF and severity of the disease.
Açıklama
Anahtar Kelimeler
familial Mediterranean fever, gene polymorphism, tumor necrosis factor-alpha
Kaynak
Clinical Rheumatology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
26
Sayı
6
