Valproic acid and lamotrigine treatment during pregnancy - The risk of chromosomal abnormality
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A baby bom to an epileptic mother had dysmorphological features associated with 47,XXX karyotype, The mother had been treated with valproic acid (1800 mg per day) and lamotrigine (100 mg per day) throughout pregnancy. Dysmorphological features detected in baby were intrauterine growth retardation, hypertelorism, flattened nasal bridge, low set malformed auriculas, micrognathia, very small an bow-shaped mouth with thin upper lip, cleft palate, arachnodactyly, camptodactyly, secundum atrial septal defect, bilateral hammer toes and decreased creases on the soles. At 6 months old she showed motor retardation. The molecular analysis of parents revealed that extra X chromosome was inherited from the mother. In this case whether the dysmorphological features and 47,XXX karyotype were caused by lamotrigine and valproic acid treatment during pregnancy or coincidence is in question. (C) 2002 Elsevier Science B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
valproic acid, lamotrigine, karyotype, chromosomes
Kaynak
Mutation Research-Genetic Toxicology and Environmental Mutagenesis
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
534
Sayı
01.Feb
