Solunum Yolu Virüs Enfeksiyonu Nedeni ile Hastaneye Yatan Çocukların Klinik ve Epidemiyolojik Olarak Değerlendirilmesi
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Solunum yolu virüsü enfeksiyonları, özellikle bebeklerde ve küçük çocuklarda hastaneye yatışların en sık nedenidir. Multip-leks polimeraz zincir reaksiyonu (PCR) ile solunum yolu virüslerinin saptanması hasta yönetimini kolaylaştırmış ve yeni virüslerin ta-nımlanmasına izin vermiştir. Bu çalışmanın amacı, hastanede yatan çocuklardaki viral ajanların insidans ve epidemiyolojik özelliklerini belirlemek ve tek virüs ile çoklu virüs enfeksiyonlarının klinik bulgu-larını karşılaştırmaktır. Gereç ve Yöntemler: Solunum yolu enfeksiyonu nedeni ile hastanede yatan çocukların verileri geriye dönük olarak araştırıldı. Hastaların de-mografik özellikleri, başvurdukları ay/mevsim, klinik ve laboratuvar bul-guları, yatış süresi, nazofarengeal sürüntü örnekleri incelendi. Solunum yolu virüsleri için multipleks PCR kullanıldı. Tek virüs enfeksiyonu olan hastalar ile çoklu virüs enfeksiyonu olan hastalar karşılaştırıldı. Bulgular: Eylül 2014-Nisan 2016 tarihleri arasında hastanede yatan çocuklardan alınan toplam 114 nazal sürüntü örneği multipleks PCR ile değerlendirildi. Hastaların 94 (%83.3)’ünde en az bir solunum pato-jeni tespit edildi. Hastaların 29 (%30.9)’unda koenfeksiyon tespit edildi. Respiratuar sinsityal virüs (RSV) (%28.7) en sık görülen patojendi ve RSV-rinovirüs en sık görülen birliktelikti (%31, 9/29). Birden fazla virüs enfeksiyonu sıklıkla daha küçük çocuklarda saptandı (p= 0.022). İki grup arasında cinsiyet, erken doğum, mekanik ventilasyon öyküsü, kronik hastalık varlığı, ailede sigara içimi öyküsü, ailede üst solunum yolu en-
Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. the aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic character-istics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respirato-ry viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common co-existence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05).
Objective: Respiratory virus infections are the most common cause of hospitalization particularly in infants and young children. Detection of the respiratory viruses with multiplex PCR has recently facilitated patient management and allowed for the identification of new viruses. the aim of this study was to determine the incidence, epidemiology of viral agents in hospitalized children and to compare the clinical manifestations of single virus versus multiple virus infections. Material and Methods: Data of hospitalized children with respiratory infections were retrospectively investigated. Demographic character-istics of the patients, the month/season they were admitted, clinical and laboratory findings, duration of hospitalization, nasopharyngeal swab samples were investigated. Multiplex PCR was used for respirato-ry viruses. Patients with a single virus infection and those with multiple virus infection were compared. Results: A total of 114 nasal swab samples from hospitalized children during September 2014-April 2016 were evaluated by multiplex PCR. At least one respiratory pathogen was detected in 94 (83.3%) of the patients. Co-infections were identified in 29 (30.9%) of the patients. RSV (28.7%) was the most common single pathogen and RSV-Rhinovirus was the most common co-existence (31%, 9/29). Multiple virus infections were mostly detected in younger children (p= 0.022). There was no difference between children with multiple versus single virus infections in terms of gender, premature birth, mechanical ventilation history, presence of chronic illness, family history of smoking, upper respiratory tract infection in the family, severity of disease (respiratory scoring, oxygen requirement), hospitalization stay, need for hospitalization in the intensive care unit and laboratory findings (p> 0.05).
Açıklama
Anahtar Kelimeler
Pediatri
Kaynak
Çocuk Enfeksiyon Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
3
