SYNTHESIS OF BENZIMIDAZOLE-SUGAR DERIVATIVES: A POTENTIAL TREATMENT FOR ALZHEIMER’S DISEASE
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Babes-Bolyai University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, a new series of chiral benzimidazole-glycosyl thiourea derivatives (5-10) were synthesized and evaluated for their inhibitory effects against hCA I, hCA II, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The structures of the benzimidazole-glycosyl thiourea compounds were determined by FTIR,1H-NMR,13C-NMR and elemental analysis. The KI values for the CA isoenzymes of the synthesized materials ranged from 6.03 to 42.98 nM. KI values for cholinesterase enzymes were shown to be between 5.32 and 39.14 nM. It was observed that compound 10 is the best hCA I inhibitor (KI:6.03 nM), compund 9 is the best hCAII inhibitor (KI:17.29 nM) and compound 8 is the best AChE (KI:5.32 nM) and the best BChE (KI:18.73 nM) inhibitor. © 2023 STUDIA UBB CHEMIA.
Açıklama
Anahtar Kelimeler
amino acid, Benzimidazole, carbonic anhydrase, cholinesterase, glycosyl thiourea
Kaynak
Studia Universitatis Babes-Bolyai Chemia
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
2023
Sayı
4
