Preparation and biodistribution of [131I]linezolid in animal model infection and inflammation

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dc.contributor.authorYurt Lambrecht F.
dc.contributor.authorYilmaz O.
dc.contributor.authorDurkan K.
dc.contributor.authorUnak P.
dc.contributor.authorBayrak E.
dc.date.accessioned2019-10-27T08:35:32Z
dc.date.available2019-10-27T08:35:32Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractLinezolid is the first of new class of antibiotics, the oxazolidinones, and exhibits activity against many gram-positive organisms, including vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and penicillin-resistant Streptococcus pneumoniae. Aim of the study: Linezolid was to label with I-131 and potential of the radiolabeled antibiotic was to investigate in inflamed rats with S. aureus (S. aureus) and sterile inflamed rats with turpentine oil. Linezolid was labeled with I-131 by iodogen method. Biodistribution of [131I]linezolid was carried out in bacterial inflamed and sterile inflamed rats. Radiolabeling yield of [ 131I]linezolid was determined as 85 ± 1% at pH 2. After injecting of [131I]linezolid into bacterial inflamed and sterile inflamed rats, radiolabeled linezolid was rapidly removed from the circulation via the kidneys. Binding of [131I]linezolid to bacterial inflamed muscle (T/NT = 77.48 at 30 min) was five times higher than binding to sterile inflamed muscle (T/NT = 14.87 at 30 min) of rats. [131I]linezolid showed good localization in bacterial inflamed tissue. It was demonstrated that [131I]linezolid can be used to detect S. aureus inflammation in rats. © 2009 Akadémiai Kiadó.en_US
dc.description.sponsorshipAcknowledgement The authors gratefully acknowledge the financial support received from the Ege University Department of Scientific Projects. --en_US
dc.identifier.doi10.1007/s10967-009-0006-x
dc.identifier.endpage419en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-009-0006-x
dc.identifier.urihttps://hdl.handle.net/11454/27252
dc.identifier.volume281en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial inflameden_US
dc.subjectI-131en_US
dc.subjectInfection detectionen_US
dc.subjectLinezoliden_US
dc.subjectS. aureusen_US
dc.titlePreparation and biodistribution of [131I]linezolid in animal model infection and inflammationen_US
dc.typeArticleen_US

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