DNA electrochemical biosensor for the detection of short DNA sequences related to the hepatitis B virus

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dc.contributor.authorErdem, A
dc.contributor.authorKerman, K
dc.contributor.authorMeric, B
dc.contributor.authorAkarca, US
dc.contributor.authorOzsoz, M
dc.date.accessioned2019-10-27T11:50:42Z
dc.date.available2019-10-27T11:50:42Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractNucleic acid hybridization forms the basis for the diagnosis of genetic and infectious diseases. Electrochemical biosensors, coupling the inherent specificity of DNA recognition reactions with the high sensitivity of physical transducers, thus hold great promise for sequence-specific detection. An electrochemical biosensor for the voltammetric detection of DNA sequences related to the hepatitis B virus (HBV) is described. Synthetic single-stranded oligonucleotides ("probe") have been immobilized onto carbon paste electrodes with the adsorption at a controlled potential. The probes were hybridized with different concentrations of complementary ('target') sequences. The formed hybrids on the electrode surface were evaluated by differential pulse voltammetry using cobalt phenanthroline, [Co(phen)(3)(3+)] as the indicator of hybridization reaction.en_US
dc.identifier.endpage588en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage586en_US
dc.identifier.urihttps://hdl.handle.net/11454/34351
dc.identifier.volume11en_US
dc.identifier.wosWOS:000081368800011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA biosensorsen_US
dc.subjecthepatitis B virus (HBV)en_US
dc.subjectcobalt phenanthrolineen_US
dc.subjectDNAen_US
dc.subjecthybridizationen_US
dc.titleDNA electrochemical biosensor for the detection of short DNA sequences related to the hepatitis B virusen_US
dc.typeArticleen_US

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