Long-term Outcome of Infants with Spina Bifida Through Assessment of the Prognostic Value of Hostile Bladder Parameters
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: In 2016, the Centers for Disease Control and Prevention published a management algorithm for Spina Bifida (SB) cases from birth and started collecting data prospectively. They designated risk factors from urodynamic studies as end filling pressure or detrusor leak point pressure (DLPP) >= 40 cm H2O or neurogenic detrusor overactivity (NDO) with detrusor sphincter dyssynergia (DSD), and categorized this type of bladder dysfunction as hostile bladder (HB). They recommended the immediate start of clean intermittent catheterization and anticholinergics in these patients. Having similar concerns regarding this patient population, we designed a retrospective study to identify and reveal the long-term outcomes of SB patients with HB. Materials and Methods: All urodynamic studies and hospital records of SB patients admitted and followed between 1994-2014 were reviewed retrospectively. The demographic data, the presence of DLPP, DSD and NDO in the first urodynamic examination, bladder compliance, first and last radiologic and scintigraphic imagings, and surgical interventions were evaluated. Upper tract damage was defined as new scars in dimercaptosuccinic acid scans. Results: A total of 58 patients were included in this study. The mean follow-up was 12.17 +/- 5.17 years. The presence of a scar in the first scintigraphy (p=0.01) and the presence of hydronephrosis in the first and last ultrasonography (p=0.03) were found to be independent risk factors for new scar development. When DLPP values were evaluated with receiver operating characteristic curve analysis, 50 cm H2O was observed as a significant threshold value with 73% sensitivity and 60% specificity. Conclusion: Our study confirmed the detrimental effects of high pressure and detrusor-sphincter dyssynergia; however, HB parameters were not sufficient to distinguish high-risk group patients. The presence of scars in the first scintigraphic evaluation, DLPP above 50 cm H2O, and the presence of hydronephrosis in the first ultrasound were found to be risk factors for renal deterioration. More frequent monitoring and detailed evaluation may be necessary for patients with these risk factors.
Açıklama
Anahtar Kelimeler
Spina Bifida, hostile bladder, neuropathic bladder, detrusor leak point pressure, neurogenic detrusor overactivity, Urinary-Tract Function, Neurogenic Bladder, Renal Scar, Children, Myelodysplasia, Pressure, Update, Dysfunction, Management, Newborns
Kaynak
Journal Of Pediatric Research
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
8
Sayı
2
