Neuroprotection by mefenamic acid against d-serine: Involvement of oxidative stress, inflammation and apoptosis
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Mefenamic acid, a non-steroidal antiinflammatory drug (NSAID), directly and dose-dependently exhibits neuroprotective activity. In our study, we investigated the effects of mefenamic acid against d-serine on oxidative stress in the hippocampus, cortex and cerebellum of rats. Furthermore, the potential inflammatory and apoptotic effects of d-serine and potential protective effect of mefenamic acid were determined at mRNA and protein levels of TNF-?, IL-1ß, Bcl-2 and Bax. We found that d-serine significantly increased oxidative stress, levels of inflammation-and apoptosis-related molecules in a region specific manner. Mefenamic acid treatment provided significant protection against the elevation of lipid peroxidation, protein oxidation, levels of TNF-?, IL-1ß and Bax. As a conclusion, we suggest that d-serine, as a potential neurodegenerative agent, may have a pivotal role in the regulation of oxidative stress, inflammation and apoptosis; and NSAIDs, such as mefenamic acid, may assist other therapeutics in treating disorders where d-serine-induced neurotoxic mechanisms are involved in. © 2012 Informa UK, Ltd.
Açıklama
Anahtar Kelimeler
Apoptosis, D-serine, Inflammation, Non-steroidal antiinflammatory drugs
Kaynak
Free Radical Research
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
46
Sayı
6
