BIOADHESIVE AND MECHANICAL PROPERTIES OF TRIAMCINOLONE ACETONIDE BUCCAL GELS
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Biyoadezif sistemler oral kavitede uzun süre yüksek etkin madde konsantrasyonu sağlaması bakımından en yaygın kullanılan ilaç taşıyıcı sistemlerdir. Ancak bukkal mukozaya uygulanacak formülasyonların kabul edilebilir mekanik özellikler taşıması gerekir. Doku profil analizi (Texture profile analysis-TPA) polimerik sistemlerin mekanik özelliklerinin tespitinde kullanılan bir yöntemdir. Bu çalışmanın amacı farklı biyoadezif polimerler kullanarak piyasa preparatına alternatif olacak yeni jel formülasyonları geliştirmek ve kullanılan polimerlerin, formülasyonların mekanik özelliklerine etkilerini incelemektir. Bu amaçla poloksamer 407, karbopol 934, kitozan ve HPMC kullanılarak triamsinolon asetonit içeren jel formülasyonları hazırlanmıştır. Hazırlanan tüm formülasyonlar %0.1 triamsinolon asetonit içeren piyasa preparatı (Kenacort-A Orabese®) ile karşılaştırılmıştır. Elde edilen sonuçlara göre formülasyonların biyoadezif özelliğinin polimer konsantrasyonuna ve kitozanın molekül ağırlığına bağlı olduğu bulunmuştur. Ayrıca kitozan içeren formülasyonlara ilave edilen HPMC ile daha iyi biyoadezif özellik elde edilmiştir. TPA sonuçlarına göre ise geliştirilen jel formülasyonlarının mekanik özelliklerinin piyasa preparatına göre daha uygun olduğunu gösterilmiştir.
Bioadhesive drug delivery systems are the most widely used approach which aims to provide high drug concentrations in the oral cavity for a long period of time. A formulation which has been designed for buccal application must exhibit acceptable mechanical characteristics. Texture profile analysis is a method which determines the mechanical properties of polymeric systems. The aim of this study was to develop different buccal gel formulations with several bioadhesive polymers for oral mucosal ulcerations as an alternative to commercial product and to compare the effect of bioadhesive polymers on the mechanical and textural properties of the gel formulations. For these purposes, the gel formulations containing Triamcinolone acetonide were prepared by using Polaxamer 407, Carbopol 934, chitosan and HPMC. All the developed formulations were compared with commercial product which is containing 0.1% triamcinolone acetonide (Kenacort-A Orabese®). According to the results, it was observed that the bioadhesive properties of the formulations depends on the bioadhesive polymer concentration and molecular weight of chitosan. It was also noted that, the bioadhesive performance of the chitosan based formulations was improved with HPMC. Texture profile analysis (TPA) results indicated that mechanical properties of the developed gels are more suitable than the commercial product.
Bioadhesive drug delivery systems are the most widely used approach which aims to provide high drug concentrations in the oral cavity for a long period of time. A formulation which has been designed for buccal application must exhibit acceptable mechanical characteristics. Texture profile analysis is a method which determines the mechanical properties of polymeric systems. The aim of this study was to develop different buccal gel formulations with several bioadhesive polymers for oral mucosal ulcerations as an alternative to commercial product and to compare the effect of bioadhesive polymers on the mechanical and textural properties of the gel formulations. For these purposes, the gel formulations containing Triamcinolone acetonide were prepared by using Polaxamer 407, Carbopol 934, chitosan and HPMC. All the developed formulations were compared with commercial product which is containing 0.1% triamcinolone acetonide (Kenacort-A Orabese®). According to the results, it was observed that the bioadhesive properties of the formulations depends on the bioadhesive polymer concentration and molecular weight of chitosan. It was also noted that, the bioadhesive performance of the chitosan based formulations was improved with HPMC. Texture profile analysis (TPA) results indicated that mechanical properties of the developed gels are more suitable than the commercial product.
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
1