Concanavalin a Grafted Nanoemulsions for Nasal Delivery: Preliminary Studies with Fluorescently Labelled Formulations
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nasal delivery is a non-invasive strategy for effective drug delivery. Nevertheless, in order to promote drug uptake by the nasal mucosa, it is fundamental to increase its residence time in the administration site. To this aim, nano-sized drug delivery systems are widely exploited. Within this context, the commercially available nanoemulsion for parenteral nutrition is a biocompatible, safe and clinically approved vehicle for drug delivery. Furthermore, the nanodroplet surface can be modified via a well-established protocol to graft Concavalin A, a lectin capable of improving the mucosal adhesion, by binding to the alpha-mannose and alpha-glucose residues of the mucosal glycocalyx. The obtained targeted formulation is able to induce haemagglutination, as opposite to non-modified nanoemulsion. Furthermore, the ConA grafting maintains the physicochemical properties of the nanodroplets (size similar to 230 nm, Z < -35 mV) and does not interfere with the loading of the Rose Bengal fluorescent probe. Fluorescently labelled ConA grafted nanodroplets showed enhanced permeation and accumulation in ex vivo bovine nasal mucosa. This study is a proof of concept that Concanavalin A can be used to decorate the surface of nanodroplets, acting as a permeation promoter.
Açıklama
Anahtar Kelimeler
lectin, nanoemulsion, nasal, permeation enhancer
Kaynak
Materials
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
17
Sayı
20
Künye
Misrakli, M., Rizzo, S. A., Bordano, V., Bozza, A., Ferraris, L., Marini, E., Muntoni, E., Capucchio, M. T., Scomparin, A., & Battaglia, L. (2024). Concanavalin a grafted nanoemulsions for nasal delivery: Preliminary studies with fluorescently labelled formulations. Materials, 17(20), 4959.
