Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

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dc.contributor.authorYilmaz, Seniha Kiremitci
dc.contributor.authorOvali, Gulgun Yilmaz
dc.contributor.authorKizilay, Deniz Ozalp
dc.contributor.authorTarhan, Serdar
dc.contributor.authorErsoy, Betul
dc.date.accessioned2024-08-31T07:50:03Z
dc.date.available2024-08-31T07:50:03Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractPurposeHeight age (HA) and bone age (BA) delay is well known in the patients with short stature. Therefore assessing pituitary hypoplasia based on chronological age (CA) might cause overdiagnosis of pituitary hypoplasia. We aimed to investigate the diagnostic and prognostic value of the PH and PV based on CA, HA, or BA in the patients with GHD.MethodsFifty-seven patients with severe and 40 patients with partial GHD and 39 patients with ISS assigned to the study. For defining the most accurate diagnosis of pituitary hypoplasia, PH and PV were evaluated based on CA, BA and HA. The relationship of each method with clinical features was examined.ResultsThe mean PV was significantly larger in patients with ISS compared to the GH-deficient patients. PV was more correlated with clinical features including height SDS, stimulated GH concentration, IGF-1 and IGFBP-3 SDS, height velocity before and after rGH therapy. We found BA-based PV could discriminate GHD from ISS (Sensitivity: 17%, specificity: 98%, positive predictive value: 94%, negative predictive value: 39%), compared to the other methods based on PH or PV respect to CA and HA. 3% of patients with ISS, 17% of patients with GHD had pituitary hypoplasia based on PV-BA.ConclusionPV based on BA, has the most accurate diagnostic value for defining pituitary hypoplasia. But it should be kept in mind that there might be still misdiagnosed patients by this method. PV is also a significant predictor for the rGH response.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK)en_US
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).en_US
dc.identifier.doi10.1007/s12020-024-03951-9
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.pmid38969909en_US
dc.identifier.scopus2-s2.0-85197565744en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-024-03951-9
dc.identifier.urihttps://hdl.handle.net/11454/105097
dc.identifier.wosWOS:001263318600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectPituitary Volumeen_US
dc.subjectPituitary Hypoplasiaen_US
dc.subjectBone Ageen_US
dc.subjectShort Statureen_US
dc.subjectRecombinant Gh Responseen_US
dc.subjectMultiple Pituitary Hormone Deficiencyen_US
dc.titlePitfalls of diagnosing pituitary hypoplasia in the patients with short statureen_US
dc.typeArticleen_US

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