MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tabriz Univ Medical Sciences & Health Services
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate gene expression on post-transcriptional level via inhibition or degradation of specific mRNAs. MiRNAs in cells are the primary regulators of functions such as cell growth, differentiation, and apoptosis and considerably influence cell function. The expression levels of microRNAs change in human diseases, including cancer. These changes highlight their essential role in cancer pathogenesis. Ubiquitous irregular expression profiles of miRNAs have been detected in various human cancers using genome-wide identification techniques, which are emerging as novel diagnostic and prognostic cancer biomarkers of high specificity and sensitivity. The measurable miRNAs with enhanced stability in blood, tissues, and other body fluids provide a comprehensive source of miRNA-dependent biomarkers for human cancers. The leading role of miRNAs as potential biomarkers in human cancers is discussed in this article. In addition, the interests and difficulties of miRNAs as biomarkers have been explored.
Açıklama
Anahtar Kelimeler
MicroRNA Biogenesis of, miRNA Cancer diagnosis, Cancer prognosis, Circulating Micrornas, Normalization Strategy, Lung, Plasma, Biomarkers, Protein, Identification, Transcription, Biogenesis, Prevention
Kaynak
Advanced Pharmaceutical Bulletin
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
13
Sayı
3
