The antinociceptive effect of moclobemide on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Ltd Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of our study was to investigate the antinociceptive activity of moclobemide on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy. The neuropathy was produced by ligation of the sciatic nerve and nociceptive thresholds were determined 15-21 days after surgery by a modification of the Randall-Sellito method. Group 1 (n = 10) received 0.2 ml peroral (p.o.) saline, Group 2 (n = 10) 5 mg kg(-1), Group 3 (n = 10) 10 mg kg(-1) and Group 4 (n = 10) 20 mg kg(-1) p.o. moclobemide. Nociceptive pressure thresholds were then measured every 20 minutes after drug administration. Analysis of variance, Tukey's test and a paired Student's t-test were employed for statistical analysis. The perorally administered moclobemide (5, 10 and 20 mg kg(-1)) produced an antinociceptive effect on both lesioned and non-lesioned hind paws (P < 0.05). However, the analgesic effect on the lesioned paw was significantly more potent than the non-lesioned paw. The peak value (p) remained constant while the maximal increment between the control threshold and the peak value (I-max) was significantly more pronounced for the lesioned paw (P < 0.001). The results of this study may suggest that moclobemide can be a therapeutic alternative to treat some clinical symptoms in peripheral neuropathic conditions. (C) 2001 Academic Press.
Açıklama
Anahtar Kelimeler
moclobemide, antinociceptive effect, sciatic nerve ligation, paw pressure, rat
Kaynak
Pharmacological Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
44
Sayı
6
