IgG subclass deficiency in extrinsic childhood asthma

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dc.contributor.authorRemziye Tanaç
dc.contributor.authorNecil Kütükçüler
dc.contributor.authorEce Özdoğru
dc.contributor.authorEsen Demir
dc.date.accessioned2019-10-26T19:53:12Z
dc.date.available2019-10-26T19:53:12Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractIgG subclass concentrations were measured in 25 extrinsic asthmatic children because IgG subclass deficiency, which reflects delayed maturation of the immune system, might have a role in pathogenesis, and other forms of immunodeficiency, such as IgA deficiency, have been associated with atopic disease. Serum total IgG, IgM, and IgA concentrations were measured by nephelometry and IgG1, IgG2, IgG3, IgG4 concentrations of the patients' sera were measured by enzyme-linked imnunosorbent assay (ELISA). IgG1, IgG2, and IgG3 were found to be below normal ranges in 8%, 16%, and 12% of asthmatic patients, respectively 28% of cases had one or more values more than three standard deviation points below the mean for age-matched controls. IgG4 concentrations were found to be raised in only 8% of patients. Partial IgA deficieny was found in one of the patients. Recurrent respiratory tract infections were observed in two of the seven patients with IgG and IgG subclass deficiencies. It was concluded that IgG subclass deficiency might cause an impairment in the clearance of adsorbed allergnes and have a role in the pathogenesis of the disease.en_US
dc.description.abstractIgG subclass concentrations were measured in 25 extrinsic asthmatic children because IgG subclass deficiency, which reflects delayed maturation of the immune system, might have a role in pathogenesis, and other forms of immunodeficiency, such as IgA deficiency, have been associated with atopic disease. Serum total IgG, IgM, and IgA concentrations were measured by nephelometry and IgG1, IgG2, IgG3, IgG4 concentrations of the patients' sera were measured by enzyme-linked imnunosorbent assay (ELISA). IgG1, IgG2, and IgG3 were found to be below normal ranges in 8%, 16%, and 12% of asthmatic patients, respectively 28% of cases had one or more values more than three standard deviation points below the mean for age-matched controls. IgG4 concentrations were found to be raised in only 8% of patients. Partial IgA deficieny was found in one of the patients. Recurrent respiratory tract infections were observed in two of the seven patients with IgG and IgG subclass deficiencies. It was concluded that IgG subclass deficiency might cause an impairment in the clearance of adsorbed allergnes and have a role in the pathogenesis of the disease.en_US
dc.identifier.endpage50en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRNeE9EUTA=
dc.identifier.urihttps://hdl.handle.net/11454/13804
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleIgG subclass deficiency in extrinsic childhood asthmaen_US
dc.typeOtheren_US

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