The synthesis and anticonvulsant activity of some omega-phthalimido-N-phenylacetamide and propionamide derivatives
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, by combining anilide and N',N'-phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen omega-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2,6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that omega-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure.
Açıklama
Anahtar Kelimeler
anticonvulsant, MES, anilide, 2-phthalimidoacetamide, 3-phthalimidopropionamide
Kaynak
Archiv Der Pharmazie
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
337
Sayı
2
