Single-shot, low-dose intratympanic gentamicin in Ménière disease: Role of vestibular-evoked myogenic potentials and caloric test in the prediction of outcome
Küçük Resim Yok
Tarih
2011
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study was to assess the efficacy and safety of single and low-dose intratympanic gentamicin therapy in patients with Ménière disease and who were monitored both with caloric tests and vestibular-evoked myogenic potentials (VEMPs) to see if VEMPs have an additional role in predicting the efficacy of the drug. Study design: This is a prospective cohort study. Setting: Tertiary referral center is the study setting. Patients: Twenty-five intractable Ménière disease patients were included as the study group. Intervention(s): Low-dose (16 mg/mL), single-shot intratympanic gentamicin was applied. VEMP and caloric test were applied 2 weeks after the application. Main outcome measure(s): Safety and efficacy of protocol were evaluated at the sixth month postoperatively with tonal audiogram and visual analog scale, respectively. Results: Mean average pure-tone hearing threshold at 0.5, 1, 2, 4, and 8 kHz was 49.6 and 51.0 dB before and after the application, respectively (P >.05). Mean pretreatment and posttreatment visual analog scale scores of patients were 17.6 mm (10-30 mm) and 74.6 mm (41-100 mm), respectively (P <.01). Posttreatment VEMPs were absent in 17, deteriorated in 2, and not changed in 6 patients. VEMP was a significant predictor of posttreatment visual analog scale score, whereas caloric test was not (P <.01). Conclusions: Low-dose, single-shot intratympanic gentamicin treatment proved to be effective and safe among intractable Ménière patients. VEMPs obtained at posttreatment second week were significant predictors of patients posttreatment sixth-month dizziness status and vertigo control. © 2011 Elsevier Inc.
Açıklama
Anahtar Kelimeler
Kaynak
American Journal of Otolaryngology - Head and Neck Medicine and Surgery
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
32
Sayı
5
