Serum soluble tumor necrosis factor receptor levels in patients with seasonal allergic rhinitis
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Prous Science, Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It is known that several inflammatory cells and cytokines play a role in allergic inflammation. Furthermore, there are seasonal changes in several mediators responsible for allergic inflammation. The aim:of this Study was to determine seasonal changes in serum concentrations Sf soluble tumor necrosis factor receptors (sTNFRs) and the relationship with disease activity and other inflammation markers such as eosinophil cationic protein (ECP) in patients with seasonal allergic rhinitis. serum levels of sTNFRI and sTNFRII were measured,before and during the pollen season in 18 patients with seasonal allergic rhinitis and in 17 healthy controls by using commercially available enzyme-linked immunosorbent assay (ELISA) kits. The serum levels of sTNFRI, sTNFRII, IgE, and ECP were significantly higher in patients than those in controls before and during season. sTNFRI, sTNFRII, and IgE levels were higher before season, whereas ECP levels were higher during season. We suggest that sTNFRs might play, regulatory roles even in early stages of allergic rhinitis when patients do not have clinical symptoms yet.
Açıklama
Anahtar Kelimeler
allergic rhinitis, seasonal rhinitis, eosinophil cationic protein, soluble tumor necrosis factor receptor
Kaynak
Journal of Investigational Allergology & Clinical Immunology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
11
Sayı
1
