Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules

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dc.contributor.authorBaşak, Kayhan
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorÇaputcu, Merve
dc.contributor.authorArda, Şule Sağlam
dc.contributor.authorAtlı, Muharrem
dc.contributor.authorGünhan, Ömer
dc.contributor.authorDemir, Derya
dc.date.accessioned2023-01-12T20:27:18Z
dc.date.available2023-01-12T20:27:18Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Fibrinoid accumulation in the larynx and increase in the subepithelial collage- nous connective tissue result in overgrowth. Mucosal epithelium may proliferate downward to organize and remove the fibrinoid accumulation. This downward proliferation may cause an invasive cancer-like image. This study focused on the pathogenesis of the accumulation of fibrinoid substance and the development mechanism of the associated squamous epithelium proliferation. Methods: Five hundred and seventy-five laryngeal nodules were reexamined and 111 of them with varying degrees of irregular downward squamous epithelial proliferation were included in the study. Immunohistochemical staining of CK5/6, CK17, CK14, collagen type I, collagen type III, collagen type IV, and fibrinogen was performed. A modified Masson’s trichrome method was used for the histochemical staining of collagen. Results: Edema was present in 18% of the acute lesions and fibrin deposition in 42%. Rela- tively mature lesions mostly contain dense collagen fibers. The intensity of collagen type III was inversely proportional to the amount of fibrin accumulation. Collagen type IV was found in the epithelial and vascular basement membranes. A decrease in fibrin staining intensity and the presence of collagen type I and type III indicated the replacement of fibrin with col- lagen. Basal-type keratins showed more pronounced staining in the regenerated areas of the epithelium. As the laryngeal subepithelial fibrinoid accumulation was replaced with collagen, regression of the lesion became difficult. Conclusion: Irregular squamous epithelial proliferation occurs independent of the stage of the lesion. Although the etiology is different, the resulting lesions are histologically similar to those seen in the ligneous mucosal diseaseen_US
dc.identifier.doi10.14744/scie.2022.47154
dc.identifier.endpage115en_US
dc.identifier.issn2587-0998
dc.identifier.issn2587-1404
dc.identifier.issue2en_US
dc.identifier.startpage109en_US
dc.identifier.trdizinid535254en_US
dc.identifier.urihttps://doi.org/10.14744/scie.2022.47154
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/535254
dc.identifier.urihttps://hdl.handle.net/11454/80236
dc.identifier.volume33en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSouthern Clinics of Istanbul Eurasiaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSubepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodulesen_US
dc.typeArticleen_US

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