A comparative study of phenolic profiles and biologicalactivities of Allium sphaerocephalon L. subsp.sphaerocephalon L. and Allium sphaerocephalon L. subsp.trachypus (Boiss. Et Spruner) K. Richter

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dc.contributor.authorEmir, Ceren
dc.contributor.authorEmir, Ahmet
dc.date.accessioned2023-01-12T20:31:56Z
dc.date.available2023-01-12T20:31:56Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractAllium sphaerocephalon subsp. sphaerocephalon, the common name is known as “Round-Headed Leek”, is an edible plant in different countries. In the present study, bulb, stem and flower extracts of A. sphaerocephalon subsp. sphaerocephalon were compared in terms of phenolic profile and enzyme inhibitory activity, with A. sphaerocephalonsubsp. trachypus which is not an edible species. Total phenolic and flavonoid contents of extracts were determined by spectrophotometrically, and bulb parts of both plants were found to be rich in phenolics. Twenty-four selected phenolic compounds were investigated qualitatively and quantitatively in the extracts by LC-MS-MS. Gallic acid (458.4-1246.4 µg/g extract) as phenolic acid and 3-O-methyl quercetin (46.6-136.2 µg/g extract) as a flavonoid were the major compounds in all extracts. In addition, enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and tyrosinase) inhibitory potentials of all samples were performed using a 96-well microplate reader. Flower parts ( IC50, 11.49 µg/mL for AChE) and bulb parts of (IC50, 16.62 µg/mL for BuChE, 65.94 µg/mL for tyrosinase) A. sphaerocephalonsubsp. sphaerocephalon were the most potent samples. Also, the results of all analyses were subjected to principal component analysis, to gain insight into the relationship between data of assays.en_US
dc.identifier.doi10.35333/jrp.2020.248
dc.identifier.endpage900en_US
dc.identifier.issn2630-6344
dc.identifier.issue6en_US
dc.identifier.startpage893en_US
dc.identifier.trdizinid451455en_US
dc.identifier.urihttps://doi.org/10.35333/jrp.2020.248
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/451455
dc.identifier.urihttps://hdl.handle.net/11454/80955
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of research in pharmacy (online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleA comparative study of phenolic profiles and biologicalactivities of Allium sphaerocephalon L. subsp.sphaerocephalon L. and Allium sphaerocephalon L. subsp.trachypus (Boiss. Et Spruner) K. Richteren_US
dc.typeArticleen_US

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