Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NLM (Medline)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21?494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56?years (SD, 9?years), 55% were women, and mean baseline CCA-IMT was 0.71?mm (SD, 0.17?mm). Over a median follow-up of 5.9?years (5th-95th percentile, 1.9-19.0?years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I2=59.4%; 14 studies; 16?297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I2=57.1%; 14 studies; 17?352 participants; 6991 incident plaques). Conclusions Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
Açıklama
Anahtar Kelimeler
carotid intima?media thickness, carotid plaque, individual participant data meta?analysis, prospective studies, atherosclerotic plaque, carotid artery disease, carotid intima-media thickness, common carotid artery, diagnostic imaging, female, human, male, meta analysis, middle aged, prospective study, risk factor, Carotid Artery Diseases, Carotid Artery, Common, Carotid Intima-Media Thickness, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Prospective Studies, Risk Factors
Kaynak
Journal of the American Heart Association
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
12
Sayı
12
