Synthesis, Characterization and Antimicrobial Studies of New Chiral Amide-Schiff Base Derivatives
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Tarih
2020
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, new chiral Schiff bases (3-9) were synthesized via the reaction of chiral amide derivatives with various substituted aromatic aldehydes. The structures of the newly synthesized compounds were characterized by FTIR, 1H-NMR, 13C-NMRand elemental analysis. All of these Schiff bases were tested in vitro against Staphylococcus aureus, Bacillus cereus, Escherichiacoli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans for theirantibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positiveand Gram-negative bacteria. Among the tested compounds compound 7 was found to show the most potent inhibitory actionagainst test organisms.
Açıklama
Anahtar Kelimeler
Kaynak
Hacettepe Journal of Biology and Chemistry
WoS Q Değeri
Scopus Q Değeri
Cilt
48
Sayı
1
