The investigation of in vitro and in vivo release of 131I-ornidazoll from polyethylene glycol-6000 suppositories
Küçük Resim Yok
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, ornidazole and polyethylene glycol-6000 (PEG), a suppository base, were labeled with 131I and 99mTc, respectively. The rectal suppositories containing either labeled or unlabeled ornidazole were prepared by fusion method using PEG 6000. The in vitro release of 131I-ornidazole from 99mTc-labeled PEG 6000 was investigated in intestinal fluid at 37C. The rotating rate of stirrer was 100 rpm. Gamma peaks of 99mTc and 131I were counted by Nal(TI) scintillation detector and the in vitro release profiles were plotted. In addition, the release profile of unlabeled ornidazole was obtained spectrophotometrically. All the release profiles obtained were compared and evaluated. On the other hand, to investigate the in vivo release, 131I-labeled ornidazole suppositories were administered by rectal route to rabbits. Scintigraphic images were taken at predetermined time intervals. In vivo release results were compared with in vitro results and a good correlation was obtained.
Açıklama
Anahtar Kelimeler
In vitro-in vivo correlation, Iodine-131, Ornidazol, Radiolabeling, Release studies, Technetium-99m
Kaynak
Acta Pharmaceutica Turcica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
41
Sayı
1
