Immunohistochemical p53 positivity has no correlation with proliferating cell nuclear antigen (PCNA) indices and histologic grade in hepatocellular carcinoma
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Immunohistochemical expression of p53 protein and its correlation with histologic grade and proliferative activity as assessed by proliferating cell nuclear antigen (PCNA) expression was investigated in 21 cases of hepatocellular carcinoma (HCC) , Conventionally processed tissue sections from all cases were stained for p53 protein and PCNA using the monoclonal antibodies Pab1801 and PC-1O, respectively. Ten of the 21 cases (47,61%), were found to have detectable evidence of p53 mutation by virtue of the immunohistochemical detection of mutant p53 protein, p53 Grades did not show correlation either with the PCNA indices or with histological grades, There was a positive correlation between the PCNA scores and histologic grades (p<O,O1). Our results indicate that p53-positive hepatocellular carcinoma is not rare m Turkey and p53 mutations 00 not seem to contribute to the histologic differentiation and proliferative activity of the tumours
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Medical Journal of Ege University
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
3
