Effect of botulinum toxin injection and pneumotic dilatation on lower esophageal sphincter in achalasia

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dc.contributor.authorBor S.
dc.contributor.authorGunsar F.
dc.contributor.authorOzutemiz O.
dc.contributor.authorMusoglu A.
dc.contributor.authorCavusoglu H.
dc.date.accessioned2019-10-27T00:26:16Z
dc.date.available2019-10-27T00:26:16Z
dc.date.issued2000
dc.departmentEge Üniversitesien_US
dc.description.abstractAlthough a number of the therapeutic techniques are used for the treatment of achalasia, none of them give satisfactory results and new treatment modalities continue to be investigated. One of these is the use of botulinum toxin injection, which was evaluated in this study by manometry, using different parameters of the lower esophageal sphincter (LES). Twenty three patients with achalasia were treated with either botulinum toxin or pneumatic dilation and compared with 13 controls. LES evaluation was performed on all patients prior to, and during the early and late stages of the procedure with rapid and stationary pull-throughs. The correlation between different manometric parameters and success of the therapy was investigated. Symptoms recurred in all patients in the botulinum group while the pneumatic dilatation group were all symptom-free. The best parameters were vector volume and the measurement of LES pressure by stationary pull- through. Pneumatic dilatation was accompanied by a great asymmetry without any adverse effect on the resolution of symptoms. Botulinum toxin injection is not an effective therapy but might be used when other options are unsuitable LES pressure measured by stationary pull-through is the most useful parameter for the evaluation of the success of therapy and the rapid pull-through technique adds no further information.en_US
dc.identifier.endpage12en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://hdl.handle.net/11454/23372
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchalasiaen_US
dc.subjectBotulinum toxinen_US
dc.subjectPneumotic dilatationen_US
dc.titleEffect of botulinum toxin injection and pneumotic dilatation on lower esophageal sphincter in achalasiaen_US
dc.typeArticleen_US

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