Evaluation of the performance of QuantiFERON (R)-TB Gold plus test in active tuberculosis patients
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim was to evaluate the sensitivity and the possible factors affecting the sensitivity of the QuantiFERON (R)-TB Gold Plus (QFT-Plus) assay in culture-positive active TB (Tuberculosis) patients, to investigate the possible causes of negative and indeterminate results in active TB patients, and to compare the QFT-Plus results of active TB patients and latent tuberculosis infection (LTBI) cases. The QFT-Plus assay was performed in 46 active TB patients and 64 LTBI. The sensitivity of the test was found as 79.5% in all culture-positive patients, 72.7% in the immunocompromised patients, and 86.4% in the non-immunocompromised patients. Compared to active TB, individuals with LTBI had a lower T-cell response and lower IFN-gamma concentrations. It was determined that the immunocompromisation reduced the sensitivity of the test and the secreted IFN-gamma concentrations and increased the indeterminate results in patients with active TB. There was no difference in secreted IFN-gamma concentrations between M. tuberculosis clones, but higher IFN-gamma concentrations in patients infected with M. tuberculosis strains compared to patients infected with zoonotic strains. Compared with active TB, response to only to TB2 was significantly higher in LTBI. In conclusion, it was concluded that TB2 tube increased sensitivity in LTBI but may not contribute to sensitivity in active TB.
Açıklama
Anahtar Kelimeler
QuantiFERON TB Gold Plus, Active TB, Spoligotyping, LTBI, T-Cell Responses, In-Tube Test, Infection, Assays, Cd4, Sensitivity, Signatures, Diagnosis
Kaynak
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
23
