Comparing the osteogenic capacities of bone substitutes: Hydroxyapatite, high-density porous polyethylene, and bone collagen: A biochemical and histological analysis
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Several inorganic materials have been shown previously to hold some osteogenic capacity. The purpose of this study is to compare the bone-forming abilities of hydroxyapatite ceramic, high-density porous polyethylene, and bone collagen within the periosteal island flap of rabbit tibia using histological and biochemical analysis. With this goal, four discrete experimental groups were formed, each comprising 22 New Zealand male rabbits. A sac was created on each rabbit tibial periosteum flap in each of the groups, and each of the previously mentioned materials was placed within this sac separately. One of these groups was thought as a control group without any material being placed inside the periosteal sac. Biopsies were taken at weeks 1, 2, 4, and 8 for biochemical analysis and at weeks 2 and 8 for histological evaluation. Neoosteogenesis was evaluated quantitatively by determination of alkaline phosphatase and osteocalcin levels biochemically as well as by the percentage of new bone formation inside the periosteal sac histologically. Results show statistically that the osteogenic effect of high-density porous polyethylene is greater than that of the other materials used in this study (P < 0.05).
Açıklama
Annual Meeting of the American-Society-of-Plastic-Surgeons/Plastic-Surgery-Educational-Foundation/American-Society-of-Maxillofacial-Surgeons -- NOV 06, 2001 -- ORLANDO, FL
Anahtar Kelimeler
osteogenesis, alloplastic materials, periosteal flap
Kaynak
Journal of Craniofacial Surgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
15
Sayı
4
