Comparison of the radiopharmaceutical potentials of dithizone radiolabeled with I-131 and with Tc-99m

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dc.contributor.authorUenak, T.
dc.contributor.authorYildirim, Y.
dc.contributor.authorAvcibasi, U.
dc.contributor.authorBiber, Z.
dc.contributor.authorDuman, Y.
dc.contributor.authorUenak, P.
dc.date.accessioned2019-10-27T19:32:47Z
dc.date.available2019-10-27T19:32:47Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, dithizone (diphenylthiocarbazone) has been separately radiolabeled with I-131 and with Tc-99m for preliminarily testing their radiopharmaceutical potentials on male albino rabbits. I-131-dithizone and Tc-99m-dithizone were intravenously injected to rabbits via their ear veins after anesthetizing with a mixture of Alfazyne and Alfamine (Serva) to determine their dynamic and static statuses in the metabolism. Also, Tc-99m as pertechnetate and I-131 as iodate were administered to rabbits as controls. Dynamic and static scintigrams were obtained using a gamma camera (Diacan Instruments). Dynamic scintigrams were obtained over the first half hour with frames of 1 minute following the administrations of the labeled compounds. Static images were obtained from posterior projection at different time intervals up to about 3 hours following the administration of the radiolabeled compounds. Tc-99m-dithizone was significantly uptaken by the pancreas in contrast to free Tc-99m. In the case of I-131-dithizone, the distribution of I-131 activity in the metabolism was clearly different than the case of free (131)stopI and the uptake of I-131-dithizone at the pancreas zone was also significant. These preliminary tests have clearly indicated that especially Tc-99m-dithizone has a significant potential to be used as a pancreatic radiopharmaceutical.en_US
dc.identifier.doi10.1007/s10967-007-0945-z
dc.identifier.endpage770en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage767en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-0945-z
dc.identifier.urihttps://hdl.handle.net/11454/39358
dc.identifier.volume273en_US
dc.identifier.wosWOS:000248612300045en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComparison of the radiopharmaceutical potentials of dithizone radiolabeled with I-131 and with Tc-99men_US
dc.typeArticleen_US

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