Anticholinesterase Compounds from Endemic Prangos uechtritzii
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the anticholinesterase effects of the extracts and isolated compounds from the roots of endemic Prangos uechtritzii Boiss & Hausskn (Apiaceae) are reported. A novel polyacetylenic compound; (+)-8-O-methyloplopantriol A along with two known polyacetylenes; (-)-panaxynol, (+)-falcarindiol and fifteen known coumarin derivatives; umbelliferone, 6-formylumbelliferone, suberosin, 7-demethylsuberosin, (+)-ulopterol, tamarin, psoralen, imperatorin, (+)-oxypeucedanin, (+)-oxypeucedanin hydrate, (+)-oxypeucedanin methanolate, (+)-marmesin, (-)-prantschimgin, (+)-decursinol, and (-)-adicardin were isolated from the hexane (Pu-HE), chloroform (Pu-CE), and methanol (Pu-ME) extracts of P. uechtritzii roots. (-)-Panaxynol, (+)-falcarindiol, 6-formylumbelliferone, (+)-decursinol, and (-)-adicardin were obtained from the genus Prangos for the first time. (+)-8-O-Methyloplopantriol A inhibited both AChE (IC50=194.5 +/- 5.8 mu M) and BChE (IC50=51.9 +/- 2.96 mu M) enzymes. (+)-Falcarindiol, 6-formylumbelliferone, 7-demethylsuberosin, tamarin, and imperatorin also exhibited BChE-specific inhibitory activities (IC50=27.88-93.86 mu M). (+)-Falcarindiol (IC50=27.88 +/- 0.91 mu M) and imperatorin (IC50=30.89 +/- 1.40 mu M) as the most active components could be led compounds to develop new BChE inhibitors with further research against Alzheimer's disease.
Açıklama
Anahtar Kelimeler
Prangos uechtritzii, Apiaceae, 8-O-methyloplopantriol A, phytochemistry, natural products, cholinesterase, In-Silico Evaluation, Alzheimers-Disease, Inhibitory-Activity, Acetylcholinesterase Inhibitors, Potential Acetylcholinesterase, Cholinesterase-Inhibitors, Guided Fractionation, Molecular-Properties, Carbonic-Anhydrase, Drug Discovery
Kaynak
Chemistry & Biodiversity
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
19
Sayı
11
