The link between bone and coronary calcifications in CKD-5 patients on haemodialysis
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford Univ Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC). Methods. In 207 CKD-5 patients, bone biopsies, multi-slice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC. Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained. Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.
Açıklama
44th Annual Congress of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA) -- JUN 21-24, 2007 -- Barcelona, SPAIN
Anahtar Kelimeler
bone turnover, bone volume, coronary calcifications, dialysis, renal osteodystrophy
Kaynak
Nephrology Dialysis Transplantation
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
26
Sayı
3
