The effect of rocuronium on neuromuscular blockade during normoventilation and moderate hyperventilation in craniotomy operations [Kraniyotomi ameliyatlarindaki normoventilasyon ve ilimli hiperventilasyon uygulamasinin rokuronyum i·le saglanan nöromüsküler blok üzerine etkisi]

In many studies it has been shown that the effects of neuromuscular drugs can be affected by PaCO2, pH changes or hypercarbia, hypocarbia. In this study, the effects of pH, PaCO2, ETCO2 changes caused by moderate hyperventilation, normoventilation to the neuromuscular block provided by rocuronium were compared. Thirty seven ASA I-II class patients aged between 18-60 years were randomly divided into two groups, one being on normoventilation, the other being whith moderate hyperventilation group. Patients recieved standart general anaesthesia. The maintenance was achieved by the mixture of 50 % O2, 50 % N2O and 1- 1.5 % isoflurane. 0.6 mg/kg rocuronium were given to both groups after the calibration. Respiratory rate were maintained according to keep ETCO2 equal to 35-40 mmHg in normoventilation group, 30-32 mmHg in moderate hyperventilation group. In the moderate hyperventilation group T1 % 25, % 50, % 75; TOF % 25, % 50, % 75 recovery times and total effect time were significantly less than in normoventilation group. As a result care must be taken to the fact that during craniotomy cases; PaCO2, ETCO2 and pH changes related to moderate hyperventilation can shorten the neuromuscular block effect time of rocuronium, and neuromuscular block monitorization will be helpful.