Evaluation of infection imaging potential of I-131-labeled imidazolium salt
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with I-131 with high efficiency. In vitro uptake experiments of I-131-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. I-131-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that I-131-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.
Açıklama
Anahtar Kelimeler
Imidazolium salt, I-131, In vitro binding, Infection detection, Biodistribution, Staphylococcus aureus
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
315
Sayı
3
