Therapeutic corneal transplant for fungal keratitisrefractory to medical therapy
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Baskent University
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To report the outcomes of therapeutic corneal transplant for managing fungal keratitis that is refractory to medical treatment. Materials and Methods: Retrospective data analyses of the medical records was performed on 17 patients who underwent a therapeutic corneal transplant for severe culture-proven fungal keratitis between October 2006 and August 2013. We evaluated demographics, fungal organism type, surgical data, recurrence presentation, disease course, follow-up, and graft status. Results: Mean patient age was 53.2 years (range, 33-81 y). The male/female ratio was 12/5. All patients had positive microscopic evaluation and positive culture results for fungal infection. The most common fungal agent was Fusarium sp. (35%). Nine patients reported a history of injury to the cornea and/or contact with plant material or soil. The mean best-corrected visual acuity at the initial visit was 2.45 logMAR unit (range, 0.52-3.10 logMAR unit). The mean follow-up was 14 months (range, 6-76 mo). Four patie nts underwent evisceration surgery because of graft lysis or uncontrolled recurrent disease. Recurrence of the fungal infection after corneal transplant was seen in 8 patients (47.05%). The graft rejection rate was 18.18%. At the final visit, 5 grafts were clear, 4 were translucent, and 2 were opaque. There were 2 phthisis bulbi owing to catastrophic disease. The mean final bestcorrected visual acuity was 1.64 logMAR unit (range, 0.22-3.10 logMAR unit). Conclusions: Although therapeutic corneal transplant has a higher incidence of infection recurrence and graft failure, it continues to be an effective treatment for uncontrolled, refractory fungal keratitis cases to save the affected eye. © Başkent University 2015 Printed in Turkey. All Rights Reserved.
Açıklama
Anahtar Kelimeler
Eye, Fungal keratitis, Penetrating corneal transplant, Therapeutic corneal transplant
Kaynak
Experimental and Clinical Transplantation
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
13
Sayı
4
