Insulin secretion-sensitivity index-2 could be a novel marker in the identification of the role of pancreatic iron deposition on beta-cell function in thalassemia major
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Japan Endocrine Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The purpose of this study is to evaluate the impact of insulin secretion-sensitivity index-2 (ISSI-2) in the identification of the role of pancreatic iron deposition on beta-cell function in thalassemia major. Tissue iron stores were measured with magnetic resonance imaging (MR1) in the liver (R2), pancreas (R2*), and heart (Tr). ISSI-2 was assessed as a novel oral glucose tolerance test-based measure of beta-cell function. Also, the Stumvoll index showing the insulin sensitivity and Stumvoll index estimating first and second phase insulin secretion were calculated. Fourteen of the 51 Thalassemia Major patients, aged 8-34 (mean 21.1 +/- 7.2) years-old, had either an impaired glucose tolerance test (n = 9, 17.6%) or diabetes mellitus (n= 5, 9.8%) referred to as the glucose dysregulation (GD) group. the median serum ferritin and the mean liver R2 and cardiac T2* values were not significantly different between the GD and normal glucose tolerance (NOT, n = 37) groups whereas pancreas R2* was significantly higher in the GD group compared to the NGT group (p= 0.004). Patients with GD showed significantly lower ISSI-2 index (p < 0.001) as well as the Stumvoll index and Stumvoll first and second phase indices compared to those with NGT (p < 0.001). All patients with GD displayed a pancreas R2* >50 Hz and ISSI-2 <2. in conclusion, Pancreas R2* MR1 combined with ISSI-2 index may be valuable parameters to identify patients at the highest risk for developing glucose dysregulation.
Açıklama
Anahtar Kelimeler
Thalassemia, Glucose dysregulation, Pancreatic iron, Beta cell function
Kaynak
Endocrine Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
66
Sayı
12
